Nutriflex Peri/Nutriflex Plus Dosage/Direction for Use

Nutriflex Peri: Due to the low glucose content Nutriflex Peri is suitable for patients with limited glucose tolerance.
Adults: The dosage and infusion rate have to be adjusted individually according to the clinical status of the patients and their requirements of amino acids, glucose, energy, electrolytes and fluid. If necessary, additional fluid, amino acid, glucose or lipid infusions may be given. In special clinical settings, e.g. parenteral nutrition during haemodialysis to compensate for dialysis related nutrients losses, higher infusion rates may have to be used.
It is recommended that Nutriflex Peri be administered continuously. A stepwise increase of the infusion rate over the first 30 minutes up to the desired infusion rate prevents possible complications.
The daily dose is: max up to 40 ml per kg body weight per day, corresponding to up to 1.6 g amino acids per kg body weight per day; up to 3.2 g glucose per kg body weight per day; up to 2800 ml for a 70 kg patient per day.
The maximum infusion rate is: 2.5 ml per kg body weight per hour, corresponding to 0.100 g amino acids per kg body weight per hour; 0.20 g glucose per kg body weight per hour.
175 ml/hour for a 70 kg patient, corresponding to 7.0 g amino acids per hour and 14.0 g glucose per hour.
Paediatric population: Nutriflex Peri is contraindicated in newborn infants, infants and toddlers <2 years of age (see Contraindications).
The dosage ranges stated below are values for guidance. The exact dosage and infusion rate should be adjusted individually according to clinical status, age, developmental stage and underlying disease. In critically ill and metabolically unstable children, it is advisable to start with lower daily dosages or infusion rates and to increase them according to the patient's condition. If necessary, additional fluid, amino acid, glucose or lipid infusions may be given.
Daily dose (2-17 years qf age): max up to 50 ml per kg body weight per day, corresponding to up to 2.0 g amino acids per kg body weight per day; up to 4.0 g glucose per kg body weight per day.
Maximum infusion rate (2 to 17 years of age): 2.5 ml per kg body weight per hour, corresponding to 0.100 g amino acids per kg body weight per hour; 0.20 g glucose per kg body weight per hour.
Patients with impaired glucose metabolism: If the oxidative metabolism of glucose is impaired (e.g. in the early post-operative or post-traumatic period or in the presence of hypoxia or organ failure), the dosage should be adjusted to keep the blood glucose level close to normal values. Close monitoring of blood glucose levels is recommended in order to prevent hyperglycaemia.
Patients with renal/hepatic impairment: The doses should be adjusted individually in patients with hepatic or renal insufficiency (see also Precautions). Nutriflex Peri is contraindicated in severe hepatic insufficiency and in severe renal insufficiency without renal replacement therapy (see Contraindications).
Duration of treatment: Treatment via a peripheral venous access should not exceed 10 days. For applications via a central venous access the duration of use is not limited. During administration appropriate supply of additional energy (preferably in the form of lipids), essential fatty acids, trace elements and vitamins is necessary.
Method of administration: Intravenous use. Suitable for infusion via peripheral or central veins.
Precautions to be token before handling or administering the medicinal product: The solution should always be brought to room temperature prior to infusion.
For instructions on aseptic mixing of the chamber contents before administration, see Cautions for Usage.
Nutriflex Plus: Nutriflex Plus is suitable for patients with normal tolerance for both glucose and fluid.
Adults: The dosage and infusion rate have to be adjusted individually according to the clinical status of the patients and their requirements of amino acids, glucose, energy, electrolytes and fluid. If necessary, additional fluid, amino acid, glucose or lipid infusions may be given. In special clinical settings, e.g. parenteral nutrition during haemodialysis to compensate for dialysis related nutrients losses, higher infusion rates may have to be used.
It is recommended that Nutriflex Plus be administered continuously. A stepwise increase of the infusion rate over the first 30 minutes up to the desired infusion rate prevents possible complications.
The daily dose is: max up to 40 ml per kg body weight per day, corresponding to up to 1.9 g amino acids per kg body weight per day; up to 6.0 g glucose per kg body weight per day; up to 2800 ml for a 70 kg patient per day.
The maximum infusion rate is: 1.6 ml per kg body weight per hour, corresponding to 0.077 g amino acids per kg body weight per hour; 0.24 g glucose per kg body weight per hour.
112 ml/hour for a 70 kg patient, corresponding to 5.4 g amino acids per hour and 16.8 g glucose per hour.
Paediatric population: Nutriflex Plus is contraindicated in newborn infants, infants and toddlers <2 years of age (see Contraindications).
The dosage ranges stated below are values for guidance. The exact dosage and infusion rate should be adjusted individually according to clinical status, age, developmental stage and underlying disease. In critically ill and metabolically unstable children, it is advisable to start with lower daily dosages or infusion rates and to increase them according to the patient's condition. If necessary, additional fluid, amino acid, glucose or lipid infusions may be given.
Daily dose (2-17 years of age): max up to 42 ml per kg body weight per day, corresponding to up to 2.0 g amino acids per kg body weight per day; up to 6.3 g glucose per kg body weight per day.
Maximum infusion rate (2 to 17 years of age): 1.6 ml per kg body weight per hour, corresponding to 0.077 g amino acids per kg body weight per hour; 0.24 g glucose per kg body weight per hour.
Patients with impaired glucose metabolism: If the oxidative metabolism of glucose is impaired (e.g. in the early postoperative or posttraumatic period or in the presence of hypoxia or organ failure), the dosage should be adjusted to keep the blood glucose level close to normal values. Close monitoring of blood glucose levels is recommended in order to prevent hyperglycaemia.
Patients with renal/hepatic impairment: The doses should be adjusted individually in patients with hepatic or renal insufficiency (see also Precautions). Nutriflex Plus is contraindicated in severe hepatic insufficiency and in severe renal insufficiency without renal replacement therapy (see Contraindications).
Duration of treatment: The duration of treatment for the indications stated is not limited. During administration appropriate supply of additional energy (preferably in the form of lipids), essential fatty acids, trace elements and vitamins is necessary.
Method of administration: Intravenous use. For infusion into central veins only.
Precautions to be taken before handling or administering the medicinal product: The solution should always be brought to room temperature prior to infusion.
For instructions on aseptic mixing of the chamber contents before administration, see Cautions for Usage.